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Carcinogenesis In a life span carcinogenicity study carried out in B6C3F1 mice, methylphenidate brought on a rise in hepatocellular adenomas, and in males only, a rise in hepatoblastomas in a everyday dose of around sixty mg/kg/working day. This dose is approximately two periods the MRHD of 60 mg/working day supplied to little ones on mg/m2 basis.O